Cytomegalovirus‐induced T‐cell proliferation and the development of progressive multifocal leucoencephalopathy following bone marrow transplantation
- 1 January 1995
- journal article
- case report
- Published by Wiley in British Journal of Haematology
- Vol. 89 (1) , 196-198
- https://doi.org/10.1111/j.1365-2141.1995.tb08930.x
Abstract
Progressive multifocal leucoencephalopathy (PML) is a rare disorder characterized by progressive demyelination within the brain. It is usually fatal and occurs when there are defects in cell-mediated immunity. We report a case of PML which developed following allogeneic bone marrow transplantation. It was preceded by the development of a persistent polyclonal expansion of large granular lymphocytes (LGLs) which appeared to rise as a consequence of cytomegalovirus infection.Keywords
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