Production and Clinical Development of a Hansenula polymorpha-Derived PEGylated Hirudin
- 31 August 2001
- journal article
- review article
- Published by Georg Thieme Verlag KG in Seminars in Thrombosis and Hemostasis
- Vol. 27 (04) , 357-372
- https://doi.org/10.1055/s-2001-16889
Abstract
This article describes the expression of the hirudin gene heterologously in the methylotrophic yeast Hansenula polymorpha, the establishment of an industrial-scale production process and the subsequent clinical development of polyethylene glycol (PEG)-hirudin. PEGylation increases the molecular weight of hirudin, thereby reducing its kidney filtration rate and immunogenicity and increasing its half-life in the circulation.Keywords
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