THE EFFECT OF FLUORINE ON CALCIUM AND PHOSPHORUS METABOLISM IN ALBINO RATS

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Abstract
The Ca and P contents of food given and of the urine and feces excreted were determined in [male] albino rats on a basal diet with and without NaF. In young growing rats (28-156 days old) 0.1% F decidedly decreased ability to retain both Ca and P; growth was stunted and legs markedly bowed. The ratio of Ca to P retention was lower in the young F-fed rats than in the controls. A decreased retention of Ca in the controls at ca. 60 days of age diminished the difference as the F-fed rats grew older. At 92 days the retention of Ca by the F-fed rats was even greater, on a body weight basis, than that of the controls, showing that the F-fed rats spread their period of retention over a longer time. F-fed rats excreted more Ca and P, and showed a higher Ca/P ratio in the feces than did the controls. Probably F affects the Ca and P metabolism by interfering with the absorption of Ca. The same effects were noted in rats given 0.05% NaF, but to a much smaller degree. When 0.05% NaF was added in adult rats a neg. P balance was frequently obtained.

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