The persistence of cloxacillin in the mammary gland when infused immediately after the last milking of lactation

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Abstract
Summary: A series of experiments has been carried out in order to develop antibiotic preparations which, when infused into the udder at drying-off, eliminate established infection and prevent new infection from occurring in the dry period. It has been shown that the persistence of antibiotic in the dry udder is affected by the solubility of the antibiotic salt, the quantity of antibiotic infused and the base in which it is formulated. Whereas 0.2 g cloxacillin as the sodium salt infused in a 3% aluminium monostearate in mineral oil base after the last milking of lactation persisted for less than 1 week, 0.5 and 1.0 g cloxacillin in the form of the benzathine salt, in a similar base, usually persisted for 3 weeks.Secretions removed from the udders of dry cows inhibited the growth ofBacillus subtilisandSarcina luteabut not 2 strains of staphylococci.