Inhibition of renal gluconeogenesis in rats by ochratoxin
- 14 June 1979
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 180 (3) , 681-684
- https://doi.org/10.1042/bj1800681
Abstract
In kidney-cortex slices from rats fed on 2.0 mg of ochratoxin A/kg per day for 2 days, gluconeogenesis from pyruvate is decreased by 26%, and renal phosphoenolpyruvate carboxykinase activity is lowered by about 55%. Gluconeogenesis from 10 mM-lactate or 20 mM-malate or -glutamine is also significantly decreased. Hepatic phosphoenolpyruvate carboxykinase is unchanged or increased, and hexokinase activity in kidney and liver remains unaffected. We conclude that ochratoxin A in vivo is an inhibitor of renal phosphoenolpyruvate carboxykinase activity, which is responsible, at least in part, for the block in renal gluconeogenesis.This publication has 19 references indexed in Scilit:
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