Dynamic Concentration of Motors in Microtubule Arrays
- 2 April 2001
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review Letters
- Vol. 86 (14) , 3192-3195
- https://doi.org/10.1103/physrevlett.86.3192
Abstract
We present experimental and theoretical studies of the dynamics of molecular motors in microtubule arrays and asters. By solving a convection-diffusion equation we find that the density profile of motors in a two-dimensional aster is characterized by continuously varying exponents. Simulations are used to verify the assumptions of the continuum model. We observe the concentration profiles of kinesin moving in quasi-two-dimensional artificial asters by fluorescent microscopy and compare with our theoretical results.Keywords
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This publication has 11 references indexed in Scilit:
- Kinesin’s processivity results from mechanical and chemical coordination between the ATP hydrolysis cycles of the two motor domainsProceedings of the National Academy of Sciences, 1999
- Kinesin’s tail domain is an inhibitory regulator of the motor domainNature Cell Biology, 1999
- Kinesin Takes One 8-nm Step for Each ATP That It HydrolyzesJournal of Biological Chemistry, 1999
- Light Chain– dependent Regulation of Kinesin's Interaction with MicrotubulesThe Journal of cell biology, 1998
- Self-organization of microtubules and motorsNature, 1997
- Direct observation of single kinesin molecules moving along microtubulesNature, 1996
- Highly processive microtubule-stimulated ATP hydrolysis by dimeric kinesin head domainsNature, 1995
- Force and velocity measured for single kinesin moleculesCell, 1994
- Bead movement by single kinesin molecules studied with optical tweezersNature, 1990
- Movement of microtubules by single kinesin moleculesNature, 1989