ON THE STIMULATION OF NEW BONE-FORMATION WITH PARATHYROID EXTRACT AND IRRADIATED ERGOSTEROL

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Abstract
Small doses of parathyroid hormone lead to osteoblast proliferation in the rat. These osteoblasts induce new bone formation. The bone of the animal so treated becomes so dense that the spongiosa of the metaphysis looks like compact bone tissue. The changes simulate those seen in humans in marble-bone disease (Morbus Albers-Schonberg). Whereas large doses of parathyroid hormone are known to produce osteitis fibrosa and bone resorption, these experiments show that small doses have the opposite effect and lead to increased bone density. Prolonged administration of irradiated ergosterol leads also to Increased bone density, but the histological features of these bones are different from those produced by parathyroid hormone.

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