In-vitro activity of cefoperazone and penicillins alone and in combination with aminoglycosides against Pseudomonas aeruginosa

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Abstract
The minimum inhibitory (MIC) and the minimum bactericidal concentrations (MBC) of cefoperazone, piperacillin, aziocillin, ticarcillin, carbenicillin, cefuroxime and cefamandole were determined for 88 clinical isolates of Pseudomonas aeruginosa. Piperacillin and cefoperazone showed the highest antibacterial activity. They were 1·3 times more active than aziocillin, 8 times more active than ticarcillin and 25 times more active than carbenicillin. Synergy experiments were carried out with 20 strains, combining cefoperazone, piperacillin, azlocillin or carbenicillin with gentamicin, tobramycin, sissomicin and amikacin. Some synergistic effects occurred in the majority of the isolates. Strong potentiation was observed with the combination piperacillin-sissomicin (85% of the isolates), cefoperazone-gentamicin (70%) and piperacillin-gentamicin (50%). The synergistic effects in the other combinations were moderate or indifferent. Antagonism was not observed.

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