Combined quantitative dynamic contrast‐enhanced MR imaging and 1H MR spectroscopic imaging of human prostate cancer

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Abstract
Purpose: To differentiate prostate carcinoma from healthy peripheral zone and central gland using quantitative dynamic contrast‐enhanced (DCE) magnetic resonance (MR) imaging and two‐dimensional 1H MR spectroscopic imaging (MRSI) combined into one clinical protocol.Materials and Methods: Twenty‐three prostate cancer patients were studied with a combined DCE‐MRI and MRSI protocol. Cancer regions were localized by histopathology of whole mount sections after radical prostatectomy. Pharmacokinetic modeling parameters, Ktrans and kep, as well as the relative levels of the prostate metabolites citrate, choline, and creatine, were determined in cancer, healthy peripheral zone (PZ), and in central gland (CG).Results: Ktrans and kep were higher (P < 0.05) in cancer and in CG than in normal PZ. The (choline + creatine)/citrate ratio was elevated in cancer compared to the PZ and CG (P < 0.05). While a (choline + creatine)/citrate ratio above 0.68 was found to be a reliable indicator of cancer, elevated Ktrans was only a reliable cancer indicator in the diagnosis of individual patients. Ktrans and (choline + creatine)/citrate ratios in cancer were poorly correlated (Pearson r2 = 0.07), and thus microvascular and metabolic abnormalities may have complementary value in cancer diagnosis.Conclusion: The combination of high‐resolution spatio‐vascular information from dynamic MRI and metabolic information from MRSI has excellent potential for improved localization and characterization of prostate cancer in a clinical setting. J. Magn. Reson. Imaging 2004;20:279–287.

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