Antibodies to the Core Protein of Lymphadenopathy-Associated Virus (LAV) in Patients with AIDS
- 20 July 1984
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 225 (4659) , 321-323
- https://doi.org/10.1126/science.6330889
Abstract
Lymphadenopathy-associated virus ( LAV ), a human T- lymphotrophic retrovirus isolated from a homosexual man with lymphadenopathy, has been causally associated with acquired immunodeficiency syndrome (AIDS). A sensitive and specific radioimmunoprecipitation test was developed for the detection of antibodies to the major core protein of LAV , p25 (molecular weight 25,000). Antibody to LAV p25 was found in the serum of 51 of 125 AIDS patients, 81 of 113 patients with lymphadenopathy syndrome, 0 of 70 workers at the Centers for Disease Control (some of whom had handled specimens from AIDS patients), and 0 of 189 random blood donors. Of a group of 100 homosexual men from San Francisco whose serum was obtained in 1978, only one had antibody to LAV p25; in contrast, of a group of 50 homosexual men in the same community whose serum was obtained in 1984, 12 had antibodies to LAV p25.Keywords
This publication has 14 references indexed in Scilit:
- Lymphadenopathy Associated Virus Infection of a Blood Donor—Recipient Pair with Acquired Immunodeficiency SyndromeScience, 1984
- HTLV-I-SPECIFIC ANTIBODY IN AIDS PATIENTS AND OTHERS AT RISKThe Lancet, 1984
- Antibodies Reactive with Human T-Lymphotropic Retroviruses (HTLV-III) in the Serum of Patients with AIDSScience, 1984
- Serological Analysis of a Subgroup of Human T-Lymphotropic Retroviruses (HTLV-III) Associated with AIDSScience, 1984
- Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDSScience, 1984
- Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDSScience, 1984
- Abnormalities of B-Cell Activation and Immunoregulation in Patients with the Acquired Immunodeficiency SyndromeNew England Journal of Medicine, 1983
- Antibodies to Cell Membrane Antigens Associated with Human T-Cell Leukemia Virus in Patients with AIDSScience, 1983
- Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)Science, 1983
- Antibodies in human sera reactive against an internal structural protein of human T-cell lymphoma virusNature, 1981