DRUG PROPHYLAXIS OF AMEBIASIS

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Abstract
Amebiasis is well recognized as a problem in institutional groups, and the occurrence of the infection in mental hospitals, particularly among highly disturbed patients, has been described repeatedly.1 The problem of control presented by these situations is difficult. Clinical cases and high carrier rates usually persist even when the environment is assiduously sanitized to minimize the hazard of transmission through food, milk, water, or formites, such as eating utensils, clothing, and bedding. The regulation of the personal hygiene of patients, which is frequently complicated by fecal incontinence and coprophagy, is fraught with obvious inherent difficulties. Under such circumstances the attainment of even partial control of transmission of amebiasis is contingent on minimizing both the excretion of cysts of Endamoeba histolytica and the environmental fecal contamination. The situation in which the present studies were conducted is illustrative of the magnitude of the epidemiological problem of amebiasis inherent in a particular

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