Efficient Synthesis of Chiral Propargyl Alcohols by Enantioselective Titanium-TADDOLate Catalyzed Addition of Dimethylzinc to 3-Trimethylsilyl-2-propynal
- 1 October 1995
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1995 (10) , 1043-1044
- https://doi.org/10.1055/s-1995-5182
Abstract
A practical and efficient synthesis of chiral propargyl alcohols was achieved by the enantioselective addition of dimethylzinc to 3-trimethylsilyl (TMS)-2-propynal (5) using titanium-TADDOLate (α,α,α’,α’-tetraaryl-2,2-disubstituted-1,3-dioxolane-4,5-dimethanolate) catalysts.Keywords
This publication has 0 references indexed in Scilit: