Inorganic salt denaturants stabilize ribonuclease against denaturation by urea
- 1 November 1978
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 56 (11) , 1003-1005
- https://doi.org/10.1139/o78-158
Abstract
The isothermal denaturation of [bovine pancreatic] RNase A by mixed denaturant systems was investigated at 25.degree. C. Low concentrations of LiCl stabilized the protein against denaturation by urea, even though the salt itself is a denaturant. This study also provides, for the first time, the most convincing evidence that the LiCl denatured RNase A contains some of the native secondary and tertiary structure.This publication has 0 references indexed in Scilit: