Multiple roles for MMPs and TIMPs in cerebral ischemia
Top Cited Papers
- 21 April 2005
- Vol. 50 (4) , 329-339
- https://doi.org/10.1002/glia.20169
Abstract
Matrix metalloproteinases (MMPs) are matrix‐degrading enzymes involved in diverse homeostatic and pathological processes. Several MMPs are expressed within the CNS and serve important normal and pathological functions during development and adulthood. An early and major pathological effect of MMP activity after cerebral ischemia is opening of the blood‐brain barrier (BBB). More recent work demonstrates emerging roles for MMPs and their natural inhibitors, tissue inhibitors of metalloproteinases (TIMPs), in the regulation of neuronal cell death. In addition, MMPs and TIMPs are likely to play important roles during the repair phases of cerebral ischemia, particularly during angiogenesis and reestablishment of cerebral blood flow. This review attempts to elucidate how MMPs and TIMPs may provide detrimental or beneficial actions during the injury and repair processes after cerebral ischemia. These processes will have important implications for therapies using MMP inhibitors in stroke.Keywords
This publication has 110 references indexed in Scilit:
- Matrix Metalloproteinase 1 Interacts with Neuronal Integrins and Stimulates Dephosphorylation of AktJournal of Biological Chemistry, 2004
- Novel Processing of β-Amyloid Precursor Protein Catalyzed by Membrane Type 1 Matrix Metalloproteinase Releases a Fragment Lacking the Inhibitor Domain against Gelatinase ABiochemistry, 2003
- Induction of matrix metalloproteinase‐9 (MMP‐9) in lipopolysaccharide‐stimulated primary astrocytes is mediated by extracellular signal‐regulated protein kinase 1/2 (Erk1/2)Glia, 2002
- Proteolytic Degradation of Alzheimer's Disease Amyloid β-Peptide by a Metalloproteinase from Microglia CellsJournal of Neurochemistry, 2002
- Blood-Brain Barrier Disruption and Matrix Metalloproteinase-9 Expression During Reperfusion InjuryStroke, 2002
- New functions for the matrix metalloproteinases in cancer progressionNature Reviews Cancer, 2002
- Neuronal extracellular proteases facilitate cell migration, axonal growth, and pathfindingCell and tissue research, 1997
- Patterns and Emerging Mechanisms of the Angiogenic Switch during TumorigenesisPublished by Elsevier ,1996
- Microvascular Basal Lamina Antigens Disappear During Cerebral Ischemia and ReperfusionStroke, 1995
- Role of angiogenesis in patients with cerebral ischemic stroke.Stroke, 1994