Estimation of the degree of crystallinity in digoxin by X-ray and infrared methods
- 1 September 1977
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 29 (1) , 684-687
- https://doi.org/10.1111/j.2042-7158.1977.tb11435.x
Abstract
The X-ray procedure for estimation of the degree of crystallinity in digoxin is based upon measurement of the total X-ray scattering and the scattering from crystalline regions of the drug. The infrared procedures are based upon measurement of the peak height ratios, 1775/1618 and 3095/1618 cm−1. Correlation between results obtained by the two methods is good. These methods are of value in the physico-chemical characterization of digoxin, particularly as the properties may be altered by comminution.Keywords
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