THE ACTIVE PRINCIPLE OF PLACENTAL TOXIN: THROMBOPLASTIN; ITS INACTIVATOR IN BLOOD: ANTITHROMBOPLASTIN

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Abstract
Tissue extracts, especially placental extracts, have long been known to possess a toxin and the toxin has many times been regarded as a causative agent in toxemia of pregnancy. It has been shown that this toxin is thromboplastin and that its lethal effect depends on intravascular clotting. The inactivator of this toxin is antithromboplastin. The possibilities that thromboplastin might be the cause of toxemia of pregnancy are reviewed. Actual proof is lacking, but there is no evidence to the contrary.

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