EFFECT OF 12-HOUR INFUSIONS OF SARALASIN OR CAPTOPRIL ON BLOOD-PRESSURE IN HYPERTENSIVE CONSCIOUS RATS - RELATIONSHIP TO PLASMA-RENIN, DURATION OF HYPERTENSION, AND EFFECT OF UNCLIPPING

  • 1 January 1981
    • journal article
    • research article
    • Vol. 98  (2) , 302-310
Abstract
Saralasin (Sar1, Ala8 angiotensin [A] II), a competitive antagonist of AII, or captopril, an A-converting enzyme inhibitor, were infused for 12 h into conscious rats with Goldblatt 2-kidney 1-clip hypertension at an early stage (mean interval from clipping 36 days) and a chronic stage (151 days). In the early phase infusions of saralasin or captopril produced a significant fall in blood pressure, which was maximal at 30 min, but the majority of animals remained hypertensive. In the chronic phase, saralasin produced a small and nonsignificant fall in blood pressure; captopril produced a fall similar to that observed in the early group. No further fall in blood pressure was seen over the 12 h period. PRC [plasma renin concentration] was markedly elevated in the early phase but did not differ significantly from normal in the chronic phase. The blood pressure fall produced by saralasin was significantly correlated with preinfusion PRC (r = 0.72 for the early group and 0.81 for the chronic group; P < 0.01); the fall in blood pressure produced by captopril was poorly correlated with PRC (r = 0.04 and 0.14, respectively). Captopril produced a minor fall and saralasin a minor elevation of blood pressure in normal animals. Infusions of dextrose without inhibitor caused no change in blood pressure. Removal of the renal artery clip normalized blood pressure in the majority (88%) of animals in either the early or chronic phases. Twelve hour infusions of the inhibitors are no more effective than 30 min infusions and do not fully correct hypertension in this model. The greater vasodepressor effect of captorpil compared to saralasin in chronic hypertensive animals and the lack of correlation between PRC and change in blood pressure with captopril suggest that this agent has an action independent from blockade of the renin-A system. Removal of the renal artery clip is more effective than renin-A blockade in correcting Goldblatt 2-kidney 1-clip hypertension.

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