Mechanism of Calcium-Induced Reptilase Clot Retraction

Abstract
Ca ions induced retraction of reptilase clots [human]. This could also be induced by thrombin. Heparin inhibited the reptilase clot retraction induced either by thrombin or Ca, but did not influence the clot retraction induced by ADP. The clot retraction induced by Ca2+ was apparently mediated by an activation of the coagulation system with the formation of thrombin.