Studies on lignan lactone antitumor agents. I Synthesis of aminoglycosidic lignan variants related to podophyllotoxin.
- 1 January 1986
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 34 (9) , 3733-3740
- https://doi.org/10.1248/cpb.34.3733
Abstract
D-(and L-)Aminoglycosidic variants of 4''-O-demethyl-1-epipodophyllotoxin were synthesized by glycosidation of 4''-O-benzyloxycarbonyl- or 4''-O-chloroacetyl-4''-O-demethyl-1-epipodophyllotoxin (8 or 22) with the corresponding aminosugar derivatives. Cyclic acetals of 1-O-(2-amino-2-deoxy- and 3-amino-3-deoxy-.beta.-D-glucopyranosyl)-4''-O-demethyl-1-epipodophyllotoxins (13 and 21) gave a significant survival time increase in mice with leukemia L-1210, and showed superior activity to VP-16-213 (etoposide, 5).This publication has 10 references indexed in Scilit:
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