ACTION OF DISTENSION UPON UTERINE GROWTH

  • 1 January 1976
    • journal article
    • research article
    • Vol. 37  (4) , 257-270
Abstract
Uterine horn growth was studied in castrated female rats under the influence of distension. One of the 2 horns was used as a control horn, to insure that no endogenous hormone was responsible for the uterine growth. Morphological studies, as well at low as at high resolution, demonstrated the ability of distension to initiate epithelial growth. The use of 3H thymidine, or H3 uridine provided some evidence for RNA synthesis 30 min after distension initiation, and DNA synthesis 24-48 h after distension onset. In these cases all the uterine tissues were involved. A possible role played by cyclic AMP was investigated using theophylline. An estrogen-like action is probably initiated by uterine distension. Results are discussed in relation to in vivo estrogen action.

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