6-Hydrxydopa-induced stimulation of ornithine decarboxylase activity in the developing rat brain.
- 1 January 1979
- journal article
- research article
- Published by Pharmaceutical Society of Japan in Journal of Pharmacobio-Dynamics
- Vol. 2 (5) , 306-308
- https://doi.org/10.1248/bpb1978.2.306
Abstract
The developmental alteration in the specific activity of ornithine decarboxylase (ODC) was investigated in the brain of rats treated with 6-hydroxydopa (6-OHDOPA) at birth. The specific activity of ODC in the cerebral hemispheres, brain stem and cerebellum declined from high level on day 4 to the non-detectable level in the adult. the neonatal treatment with 6-OHDOPA (75 mg/kg, s.c., 3 days) produced the rapid increase of ODC activity in the cerebral hemispheres and the brain stem in the 4- and 5-day-old rat. An injection of 6-OHDOPA appears to affect cellular activity of catecholamine neurons and glial cells in the developing brain.This publication has 3 references indexed in Scilit:
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- Effect of 6-hydroxydopamine on ornithine decarboxylase activity in central monoaminergic systems of ratBiochemical Pharmacology, 1977
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