Presence of HTLV-I proviral DNA in patients with adult T-Cell leukemia/lymphoma in Taiwan

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Abstract
Lymphomatoid granulomatosis (LG) and polymorphic reticulosis (PR), originally described as distinct entities, now are considered as a single disease process. Common histopathologic features include necrosis, vasculitis, and a granulomatous infiltrate. Such features have led to consider lymphomatoid granulomatosis as a systemic vasculitis; alternatively the possible emergence of an overt lymphoma has suggested that it could be a lymphoproliferative process. To investigate this later hypothesis, the authors analyzed the cellular infiltrate of tissue specimens from two patients with histologic features of LG. The analysis included the study of T‐cell antigen expression and DNA rearrangement of the beta T‐cell receptor gene. In one patient, the T‐cell phenotype of infiltrating cells was abnormal because of antigen loss. In both patients, the cells contained rearranged DNA indicating the presence of a clonal T‐cell proliferation. It is concluded that some cases of LG and PR, if not all, are related to a neoplastic T‐cell lymphoproliferative disorder.

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