Increased alpha-adrenergic receptor affinity in resistance vessels from hypertensive rats.
- 1 June 1988
- journal article
- abstracts
- Published by Wolters Kluwer Health in Hypertension
- Vol. 11 (6_pt_2) , 635-638
- https://doi.org/10.1161/01.hyp.11.6.635
Abstract
Alpha-Adrenergic receptor-related properties, specifically, norepinephrine affinity, occupancy and reserve during contraction, were determined in segments of rat resistance arteries. These were obtained from the superior mesenteric bed of spontaneously hypertensive rats and Wistar-Kyoto strain controls. Receptor affinity for norepinephrine in the spontaneously hypertensive rats was significantly greater than that for the Wistar-Kyoto controls. There were no differences in the estimates of receptor occupancy and reserve. This finding taken together with other studies is consistent with the conclusion that increased alpha-adrenergic receptor-mediated sensitivity of vascular smooth muscle of the spontaneously hypertensive rat reflects differences in the agonist site on the alpha-adrenergic receptor.Keywords
This publication has 17 references indexed in Scilit:
- Electron spin resonance studies of erythrocytes from spontaneously hypertensive rats and humans with essential hypertension.Hypertension, 1987
- Physiological Variation in α-Adrenoceptor-Mediated Arterial Sensitivity: Relation to Agonist AffinityScience, 1986
- Adrenergic Receptors in Hypertension: Radioligand Binding StudiesJournal Of Hypertension, 1985
- Distension‐dependent changes in noradrenaline sensitivity in small arteries from the ratActa Physiologica Scandinavica, 1985
- Antagonism by the tetramine disulfide benextramine of the inhibitory effects mediated by prejunctional alpha2-adrenoceptors and by postjunctional histamine H2 receptors in the mouse vas deferensCanadian Journal of Physiology and Pharmacology, 1984
- Changes in noradrenaline sensitivity and morphology of arterial resistance vessels during development of high blood pressure in spontaneously hypertensive rats.Hypertension, 1980
- Abnormal Membrane Characteristics of Erythrocytes in Rat Models and Men with Predisposition to StrokeClinical and Experimental Hypertension, 1980
- Mechanical properties of vascular smooth muscle cells in situNature, 1976
- A direct method for recording tension changes in the wall of small blood vessels in vitroInflammation Research, 1972
- COMPARISON OF DISSOCIATION CONSTANTS AND OF RELATIVE EFFICACIES OF SELECTED AGONISTS ACTING ON PARASYMPATHETIC RECEPTORS*Annals of the New York Academy of Sciences, 1967