Systemic Lupus Erythematosus in Twin Sisters Following Ten Years of Hyperglobulinemic Purpura (Waldenström)

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Abstract
Uniovular twin sisters were diagnosed 10 yr ago as having hyperglobulinemic purpura at age 12. The diagnosis was documented by purpura of the lower extremities, increased .gamma.-globulin after serum electrophoresis, and increased 7S component upon ultracentrifugation. There was also an elevated ESR [erythrocyte sedimentation rate], a positive rheumatoid arthritis latex test, and their LE [Lupus erythmatosis] preparations was negative at that time. At a later date both developed polyarthritis. After 9 yr for 1 and 10 yr for the other, their LE preparations became strongly and constantly positive, while their .gamma.-globulin remained within abnormal limits.