Bicarbonate and chloride transport across rat ileal basolateral membrane

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Abstract
The mechanisms of HCO 3 − and Cl− transport across basolateral membranes from rat ileum were investigated in isolated vesicles by means of uptake experiments. Neither Cl−/HCO 3 − exchanger nor Na+−(HCO 3 − )n cotransport seem to be present in ileal basolateral membranes. Moreover Cl− uptake is unaffected bycis Na+ and/or K+ gradients, indicating the absence of Na+−Cl−, K+−Cl− and Na+−K+−2Cl− symport activity. An electrically conductive pathway seems to be responsible for both HCO 3 − and Cl− fluxes. Evidence is also given for the presence of a Na+/H+ exchanger at the basolateral pole of ileal enterocytes.

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