PROLACTIN RESPONSES TO THYROTROPHIN RELEASING HORMONE DO NOT DISTINGUISH PATIENTS WITH ISOLATED GONADOTROPHIN DEFICIENCY FROM NORMALS

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Abstract
Prolactin secretion in response to TRH was assessed in 6 patients with isolated gonadotrophin deficiency (IGD) and in 8 normal controls. In all 6 subjects with IGD, serum estradiol was below the detection limit of the method. There was no statistical difference between either the basal or maximum increment of serum prolactin between the 2 groups. Recent claims that prolactin responses to TRH distinguish constitutional delay of puberty from IGD have therefore not be supported.

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