Investigations of animal blood samples after fragrance drug inhalation by gas chromatography/mass spectrometry with chemical ionization and selected ion monitoring

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Abstract
The fragrance compounds linalool (1) and linalyl acetate (2) could be detected, identified and quantified (1: 7–9 ng ml−1; and 2: 1–2 ng ml−1 and 4–5 ng ml−1 as free linalool) in blood samples after inhalation in animal experiments (mice) by gas chromatography/mass spectrometry (GC/MS) with chemical ionization (CI) (ammonia); selected ion monitoring (SIM) mode (1: m/z 81, 137 and 154; 2: 47, 57 and 137) and GC/flame ionization detection (FID). The inhalation of these monoterpenes in concentrations of 5 mg I−1 air leads to a significant reduction of the motility of the test animals down to 30–40% with respect to the control group.