Evidence of Increased Oxalate Absorption in Patients with Calcium-Containing Renal Stones

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Abstract
The possible roles of diet and intestinal absorption in increased excretion of oxalate by patients with renal Ca stones were studied. Dietary surveys showed that the mean daily intake of oxalic acid by stone-formers was not significantly different from that of non-stone-formers. Mean urinary excretion of oxalate, expressed as an oxalate/creatinine molar ratio, was significantly reduced by fasting, the change being more marked in stone-formers than in the normal subjects. Moreover, fasting abolished the difference in mean oxalate/creatinine ratios between stone-formers and control subjects. Small increases in urinary oxalate excretion which occur in some idiopathic calcium oxalate stone-formers were due to increased absorption of oxalate from the intestine, which may be due to a reduction in intraluminal Ca concentration.

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