EFFECT OF HYPOPHYSECTOMY ON SECRETION OF PORCINE THYROCALCITONIN IN VIVO

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Abstract
The surgically isolated thyroid gland in the pig has been shown to secrete thyrocalcitonin (TC) when perfused with an artificial medium, hypercalcaemic with respect to ionized calcium concentration (Care & Gitelman, 1968). Therefore, hypophysial hormones must not be essential for the release of at least some TC stimulated by hypercalcaemia. The present work was designed to evaluate quantitatively the effect of previous hypophysectomy on the rate of secretion of TC in response to a given degree of hypercalcaemia. In preliminary experiments, a pair of litter-mate male piglets, 19 days old, was selected and one was hypophysectomized by an adaptation of the method of Liggins, Kennedy & Holm (1967). At autopsy, hypophysectomy was confirmed by visual examination of the sella turcica. Nine days after operation, the thyroid was isolated in situ and perfused with hypercalcaemic blood (6·7 m-equiv.Ca/1.) for 2 hr. according to the method of Care (1965). The thyroid of

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