Cholera toxin and analogues of cyclic AMP stimulate the growth of cultured human mammary epithelial cells
- 1 March 1980
- journal article
- research article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 102 (3) , 317-321
- https://doi.org/10.1002/jcp.1041020306
Abstract
The growth of human mammary epithelial cells is stimulated by cholera toxin and analogues of cyclic AMP, while the growth of breast derived fibroblasts is inhibited. These compounds have little effect on DNA synthesis in the absence of other mitogens but show a synergistic effect with serum and/or EGF. The results suggest that high intracellular levels of cyclic AMP in human mammary epithelial cells increase the growth response of the cell to mitogens.This publication has 14 references indexed in Scilit:
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