The fetal fraction of cell-free DNA in maternal plasma is not affected by a priori risk of fetal trisomy

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Abstract
To determine the relationship between a priori risk for fetal trisomy and the fraction of fetal cell-free DNA (cfDNA) in maternal blood. A comparative analysis on fetal cfDNA amounts was performed in subjects stratified into a priori risk groups based on maternal age, prenatal screening results, or nuchal translucency measurement. Across the highest and lowest deciles within each group, there were no significant differences in the fetal cfDNA fraction. These data support the concept that non-invasive prenatal test performance as determined by fetal cfDNA fraction is not predicted to be different based on patient risk classification.