Labile Factor Depression in Scorbutic Guinea Pigs

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Abstract
The hemorrhagic manifestations of scurvy are caused by both increased capillary fragility and abnormal blood coagulation. Guinea pigs fed a vitamin C-deficient diet developed a moderately severe deficiency of labile factor (V) and fatty metamorphoses of the liver. The isolated deficiency of labile factor suggested that it was caused by diminished synthesis in the damaged liver. Hemorrhagic manifestations of scurvy are probably worse in guinea pigs than humans because of the normal occurrence of a low concentration of stable factor (VII) in blood from these animals.

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