An examination of the generation-time effect on molecular evolution.
Open Access
- 15 November 1993
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 90 (22) , 10676-10680
- https://doi.org/10.1073/pnas.90.22.10676
Abstract
By using DNA sequences of 17 mammalian genes, the generation-time effect is estimated separately for synonymous substitutions and nonsynonymous substitutions. Star phylogenies composed of rodentia, artiodactyla, and primates are examined. The generation-time effect is found to be more conspicuous for synonymous substitutions than for non-synonymous substitutions, by using the methods of (i) Nei and Gojobori, (ii) Li, and (iii) Ina. The proportion of accepted amino acid substitutions in evolution is estimated to be about twice as large in the primate lineage as in the rodent lineage. This result is in accord with the nearly neutral theory of molecular evolution.Keywords
This publication has 54 references indexed in Scilit:
- Evolution of the Zfx and Zfy genes: rates and interdependence between the genes.Molecular Biology and Evolution, 1993
- Cloning and characterization of the growth hormone-dependent insulin-like growth factor binding protein (IGFBP-3) in the ratBiochemical and Biophysical Research Communications, 1990
- Deletion of 3′ untranslated region of human BSF-2 mRNA causes stabilization of the mRNA and high-level expression in mouse NIH3T3 cellsBiochemical and Biophysical Research Communications, 1989
- Nucleotide and deduced amino acid sequence of a γ subunit of bovine fibrinogenNucleic Acids Research, 1989
- Mouse Serum Growth Hormone (GH) Binding Protein has GH Receptor Extracellular and Substituted Transmembrane DomainsMolecular Endocrinology, 1989
- Molecular Cloning and Expression of Rat Interleukin-1α cDNAThe Journal of Biochemistry, 1989
- Nucleotide sequence of human muscle acetylcholine receptor β-subunitNucleic Acids Research, 1989
- Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells.Proceedings of the National Academy of Sciences, 1989
- Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells.Proceedings of the National Academy of Sciences, 1988
- Stimulation of B-cell progenitors by cloned murine interleukin-7Nature, 1988