Influence of the leaving group on the rate of phosphorylation
- 1 January 1969
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society B: Physical Organic
- p. 325-329
- https://doi.org/10.1039/j29690000325
Abstract
The rates of alkaline hydrolysis and reaction with n-butylamine of a series of phosphorylating agents of general formula (PriO)2POX, [X = F, Cl, CN, and (PriO)2P:O] are measured. The different rate orders are explained in terms of the relative leaving-group tendencies of X, H2O, and BuNH2 in transient penta-covalent intermediates. The general-base catalysis of the hydrolysis of the fluoridate by n-butylamine is discussed.Keywords
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