Enhancement of the Antitumor Effect of 1,3-Bis(2-Chloroethyl)- 1-Nitrosourea by Chlorpromazine and Caffeine2
- 1 October 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 51 (4) , 1323-1325
- https://doi.org/10.1093/jnci/51.4.1323
Abstract
Murine L1210 leukemia, combined with chlorpromazine, 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), and caffeine, markedly increased survival of mice over treatment with BCNU alone. All 3 drugs had to be given together, because neither chlorpromazine plus BCNU nor BCNU plus caffeine treatment improved survival relative to an appropriate control group. The optimal time for chlorpromazine treatment was 6 hours before BCNU. Prior exposure to caffeine of both recipient mice and L1210 cells used for transplantation did not affect therapeutic response. The mechanism of enhancement of BCNU by chlorpromazine and caffeine is unknown.Keywords
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