An investigation of Ki-1 positive large cell lymphoma with antibodies reactive with tissue macrophages

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Abstract
The diagnosis of true histiocytic lymphoma (THL) represents one of the most difficult and controversial areas of lymph node pathology. Recently, Stein et al. (1985) have demonstrated that a series of tumours presenting with morphological and immunocytochemical features, previously considered as being indicative of THL, share antigenic markers with Reed-Sternberg and mononuclear Hodgkin's cells and, therefore, may be derived from lymphocytes, rather than histiocytes. In this study we have re-investigated some of these cases with a panel of monoclonal antibodies variously reactive with macrophages. Although all cases contain a heavy infiltrate of reactive histiocytes the tumour populations are negative for histiocyte antigens.