The effect of 6-azauridine on the contractile responses of the isolated ileum of the guinea-pig to drugs and to coaxial stimulation

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Abstract
Small concentrations of 6-azauridine augmented the contractions of the guinea-pig isolated ileum to acetylcholine, nicotine, histamine, barium chloride and to coaxial stimulation. High concentrations partially inhibited all the responses. After prolonged contact with high concentrations of 6-azauridine, the anti-spasmogenic effect persisted long after washing out the compound. The acetylcholine output did not change under these conditions. Comparison of the actions of 6-azauridine with those of papaverine is made and the possible mechanisms of action are discussed.