Impaired immunity in patients with inflammatory bowel disease and hyposplenism: the response to intravenous phi X174.
Open Access
- 1 March 1981
- Vol. 22 (3) , 187-189
- https://doi.org/10.1136/gut.22.3.187
Abstract
Eight patients with inflammatory bowel disease were tested for their ability to mount a serological response to the intravenous particulate antigen phi X174. Seven patients had extensive ulcerative colitis and one patient extensive Crohn's colitis, four having severe hyposplenism and four normal splenic function. The antibody response to phi X174 was grossly impaired in those with hyposplenism.This publication has 6 references indexed in Scilit:
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- The immune response of phiX 174 in man. III. Evidence for an association between hyposplenism and immunodeficiency in patients with coeliac disease.Gut, 1975
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- The immune response to thetaX 174 in man. I. Primary and secondary antibody production in normal adults.1973
- Lymphoreticular dysfunction in idiopathic steatorrhoea.Gut, 1966
- The role of the spleen in immunity. With special reference to the post-splenectomy problem in infants.1966