SIGNIFICANCE OF URINARY HYDROXYPROLINE IN MAN

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Abstract
Several factors that might affect the urinary excretion of hydroxyproline were studied in 5 normal subjects and in 3 patients with Marfan''s syndrome. Urinary excretion of hydroxyproline did not decrease in subjects changed from a normal to a low hydroxyproline diet, or to an isocaloric low protein diet. No diurnal variation in urinary hydroxyproline was found, and hydration or dehydration did not alter excretion. Ingestion of free hydroxyproline produced an increased excretion of the free form, but no change in the excretion, the peptide form which normally accounts for nearly all of the hydroxyproline in urine. Ingestion of large amounts of hydroxyproline as gelatin., increased the excretion of hydroxyproline peptides. Bound hydroxyproline normally found in urine therefore probably arises from collagen breakdown, the amount excreted being an index of the rate of degradation of this protein.