Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor
- 6 November 2005
- journal article
- research article
- Published by Springer Nature in Nature Medicine
- Vol. 11 (12) , 1293-1294
- https://doi.org/10.1038/nm1321
Abstract
Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10–14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection.Keywords
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