Enzymes and catalysts. II. Pig liver esterase-catalyzed asymmetric synthesis of (-)- and (+)-cucurbitine and its (-)-thio analogue.
- 31 December 1986
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 35 (9) , 3845-3849
- https://doi.org/10.1248/cpb.35.3845
Abstract
The asymmetric synthesis of (-)- and (+)-cucurbitine was carried out by a method involving 1,3-dipolar cycloaddition of the intermediary azomethine ylide and pig liver esterase (PLE)-catalyzed hydrolysis. The thio analogue, (-)-3-aminotetrahydrothiophene-3-carboxylic acid, was also synthesized.This publication has 0 references indexed in Scilit: