Activity of and Resistance to Moxifloxacin in Staphylococcus aureus
Open Access
- 1 April 2003
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 47 (4) , 1410-1415
- https://doi.org/10.1128/aac.47.4.1410-1415.2003
Abstract
Moxifloxacin has enhanced potency against Staphylococcus aureus , lower propensity to select for resistant mutants, and higher bactericidal activity against highly resistant strains than ciprofloxacin. Despite similar activity against purified S. aureus topoisomerase IV and DNA gyrase, it selects for topoisomerase IV mutants, making topoisomerase IV the preferred target in vivo.Keywords
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