Pyrethroid Insecticides: Esterase Cleavage in Relation to Selective Toxicity

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Abstract
The ester group of primary alcohol chrysanthemates is cleaved by mouse hepatic microsomal esterases, more rapidly for the (+)- trans than for the (+)- cis isomers. Substrate-specificity and inhibition studies in vivo establish that these pyrethroid-hydrolyzing esterases probably contribute to the low mammalian toxicity of bioresmethrin and other (+)- trans chrysanthemate insecticide chemicals derived from primary alcohols.