Modulation of β‐oxidation and proton conductance pathway of brown adipose tissue in hypo‐ and hyperinsulinemic states
- 23 January 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 166 (1) , 141-145
- https://doi.org/10.1016/0014-5793(84)80060-5
Abstract
The metabolic capacity of interscapular brown adipose tissue of hypoinsulinemic (diabetic) rats is decreased and a reduced β-oxidative capacity contributes to this metabolic alteration. It was thus of interest to compare, in diabetic and in chronically (8 days) insulin-infused rats, the β-oxidative capacity and indices of the thermogenic state (GDP-binding and 32 000 M r protein) in this tissue. Mitochondrial GDP-binding and 32 000 M r protein were both decreased in diabetic rats compared to appropriate controls and markedly increased as was also the β-oxidative capacity in hyperinsulinemic rats.Keywords
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