An artificial amino acid radiopharmaceutical for single photon emission computed tomographic study of pancreatic amino acid transports123I-3-iodo-alpha-methyl-L-tyrosine
- 1 September 1992
- journal article
- research article
- Published by Springer Nature in Annals of Nuclear Medicine
- Vol. 6 (3) , 169-175
- https://doi.org/10.1007/bf03178309
Abstract
123I-3-iodo-alpha-methyl-L-tyrosine (123I-L-AMT) was selected and its characteristics on pancreas accumulation, metabolic selectivity and metabolic stability of125I-L-AMT were studied. The studies on rat tissue slice as well as mouse biodistribution proved very high accumulation of125I-labeled L-AMT in the pancreas, which was remarkably inhibited by the active transport inhibitor, ouabain.125I-L-AMT does not enter into protein synthesis and general amino acid catabolism. Moreover,125I-L-AMT was very stable against enzymatic deiodination. Thus, the above studies indicated that the123I-labeled L-AMT was an “artificial amino acid” radiopharmaceutical to be used for the selective measurement of the membrane amino acid transport rate in the pancreas.Keywords
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