Biological glycosidation of macrolide aglycones. II. Isolation and characterization of desosaminyl-platenolide I.
- 1 January 1978
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 31 (4) , 309-318
- https://doi.org/10.7164/antibiotics.31.309
Abstract
Biological glycosidation of platernolide I, a biosynthetic intermediate of 16-membered macrolide antibiotic platenomycin aglycones, with desosamine by Streptomyces producing 14-membered macrolide antibiotics was attempted. S. narbonensis, producing narbomycin, gave a new product designated as 5-O-desosaminyl-platenolide I (III), and S. venezuelae, producing narbomycin and picromycin, gave III and a 2nd new product, 5-O-desosaminyl-14-hydroxyplatenolide I. A nonantibiotic-producing blocked mutant of S. platensis ssp. malvinus, a producer of platenomycins, converted III to an antibiotically active compound identified as 3-O-propionyl-5-O-desosaminyl-9-dihydro-18-oxo-platenolide I.This publication has 4 references indexed in Scilit:
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- A new semisynthetic macrolide antibiotic 3-O-oleandrosyl-5-O-desosaminylerythronolide a oxime.The Journal of Antibiotics, 1976
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