Mouse models for HIV-1 infection

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Abstract
The generation of small animal models, which preserve the ability for the generation of primary and memory immune responses of the engrafted human immune cells and in which a robust HIV‐1 infection may occur, may enable the rapid screening, development and evaluation of HIV‐1 protective vaccines and adjuvants. This manuscript reviews the existing mouse HIV‐1 models used to study virologic, immunologic and pathogenic aspects of HIV‐1 infection and disease and discusses their limitations and advantages, especially in the context of vaccine development, with special focus on the recently developed Trimera‐HIV‐1 animal model.