Pharmacokinetics of ceftazidime in patients with biliary tract disease
- 1 January 1986
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 31 (3) , 327-331
- https://doi.org/10.1007/bf00981132
Abstract
After administration of ceftazidime as a 1 g i.v. bolus injection, its concentration was measured by HPLC at frequent intervals in serum, bile and tissue from different parts of the biliary tract in 32 patients undergoing operation for biliary tract disease. In bile from the functioning gallbladder and common bile duct, a high concentration of ceftazidime was found, mean 18.5 and 26.6 mg/l, respectively. In bile from the non-functioning gallbladder, a very low concentration was found (Enterobacteriaecae commonly responsible for biliary tract infection.This publication has 14 references indexed in Scilit:
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