RNA interference: on the road to an alternate therapeutic strategy!
- 13 November 2003
- journal article
- review article
- Published by Wiley in Reviews in Medical Virology
- Vol. 13 (6) , 373-385
- https://doi.org/10.1002/rmv.407
Abstract
RNA interference (RNAi) is a newly described natural biological phenomenon mediated by small interfering RNA (siRNA) molecules which target viral mRNA for degradation by cellular enzymes. RNAi has become a method of choice for studying gene function, especially in mammalian systems. With proof‐of‐concept studies already presented against a wide variety of human pathogens and several innovative methods of delivering the siRNA to a wide variety of primary cells available, the role for siRNA as a potential therapeutic strategy is becoming increasingly clear. This review presents recent advances in this direction. Copyright © 2003 John Wiley & Sons, Ltd.Keywords
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