Design of molecular control mechanisms and the demand for gene expression.
Open Access
- 1 December 1977
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 74 (12) , 5647-5651
- https://doi.org/10.1073/pnas.74.12.5647
Abstract
Regulation by a repressor protein is the mechanism selected when, in the organism''s natural environment, there is low demand for expression of the regulated structural genes. Regulation by an activator protein is selected when there is high demand for expression of the regulated structural genes. These general conclusions are useful in relating physiological function to underlying molecular determinants in a wide variety of systems [in microbes and eukaryotes] that includes repressible biosynthetic pathways, inducible biosynthetic enzymes, inducible drug resistance, prophage induction and inducible catabolic pathways, for which a special case of this prediction previously was reported.Keywords
This publication has 60 references indexed in Scilit:
- Involvement of arginine in in vitro repression of transcription of arginine genes C, B and H in Escherichia coli K 12Biochemical and Biophysical Research Communications, 1976
- GENE EXPRESSION IN SOMATIC CELL HYBRIDSAnnual Review of Genetics, 1974
- Persisting Bacteriophage Infections, Lysogeny, and Phage ConversionsAnnual Review of Microbiology, 1974
- Fine structure analysis of a eukaryotic multifunctional geneNature, 1974
- Repression of tryptophan operon RNA synthesis by trp repressor in an in vitro coupled transcription—translation systemFEBS Letters, 1974
- A frameshift mutation that elongates the penicillinase protein of Bacillus licheniformisJournal of Molecular Biology, 1973
- DEVELOPMENTAL PATHWAYS FOR THE TEMPERATE PHAGE: LYSIS VS LYSOGENYAnnual Review of Genetics, 1972
- Genetic control of the l-α-glycerophosphate system in Escherichia coliJournal of Molecular Biology, 1968
- Study of Microbial Evolution through Loss of Biosynthetic Functions: Establishment of “Defective” MutantsNature, 1967
- The uptake of amino acids by isolated segments of rat intestine II. A survey of affinity for uptake from rates of uptake and competition for uptakeBiochimica et Biophysica Acta, 1960